Hello Respected All,
My name is Harihar Sharma father of Miss Shristi Sharma. She is 27 years of age From Anandaban-7, Rupandehi, Nepal. According to her medical condition she was normotensive and non-diabetic Female was diagnosed as Lambert and Cell histiocytosis in April 2013. She had a C/O of low backache for which she was investigated and MRI L-S spine and bone scan showed multiple skeletal lesion. Biopsy was done from Ileac crest (April 2013) revealed Langerhans Cell histiocytosis (S-100 positive). PET CT done on June 2013 S/O supraclavicular and mediastinal Lymphadenopatay with multiple bone metastasis. She was on alternative treatment since 1 year. PET CT done on 22/05/2014 showed progressive disease with involvement of new omental lesion. In view of that we planned for Vinblastine and prednisolone based Chemotherapy in other centre. She received 6 weeks of induction and 13 maintenance cycle till 2015. PET CT done on 15/10/2015 showed residual skeletal lession and Lymphnodes (mediastinal, bilateral supraclavicular and retroperitoneal). New mediastinal and retroperitoneal Lymphnodes are seen.
We sent her to TEACHING HOSPITAL, Tribhuvan University, Kathmandu, Nepal with C/O of cervical Lymphnodes and Biopsy was done. Cervical Lymphnode reaveled classical Hodgkin Lymphoma ( CD 30 and CD 15 positive). In view of classical Hodgkin Lymphoma, Advanced, Non bulky, she received VII cycle of ABVD Chemotherapy however could not received VIII th cycle of ABVD due to respiratory symptoms. Radiotherapy was not done. Post VII cycle of ABVD, PET Scan whole body was done which revealed lytic destruction of D12 associated with soft tissue component and small value nodes in neck and mediastinum. No metabolically active lesion.
We complained of progressive weakness of Right lower limb and for which she was evaluated with MRI (01/09/2018) spine which showed intradural lesion at L2 and L3 level. Biopsy with laminectomy was done and revealed suspicious of recurrence of Hodgkin Lymphoma. However, due to the extensive necrosis and scanty viable tissue IHC was not done. TB PCR was negative. She underwent PET CT Scan which revealed Hypermetabolic Marrow uptake and at multiple sites or vertebral bodies and long bones with SUV max 4.42. Hypermetabolic soft tissue lesion, canal L2 SUV max 0.25. We planned for salvage Chemotherapy/Brentuximab followed by ASCT.
She completed 2nd cycle of DHAP with IT methotrexate. Her CSF shows persistent lymphocytosis after 2nd cycle but minimal lymphocytes remaining. She developed Cisplatin induced ototoxicity.
This long time of treatment processing myself and my family spent a huge amount of money, time and efforts for her cure. Now a days we have a less amount that could not enough for her further treatment. I appeal to all big hearts to donate her or if possible make a programme for fund rising campaign. No Donation is small even a small drop of amount can be a huge. My daughter struggling to live a life. If you can donate us I will be always thankful if not then please pray for her fast recovery. I believe in heart touching motto " If you help Me someday I can help you."
Bank: NIC ASIA
Branch: Manigram, Ruapndehi, Nepal
A/C of : Mr. Harihar Sharma
A/C No: A502003950252401
Ph No. : +9779846104144
Swift Code: NICENPKA