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Update posted by Myleen Fetalvo On Oct 26, 2017

IgA nephropathy

IgA nephropathy is a kidney disorder in which antibodies called IgA build up in kidney tissue. Nephropathy is damage, disease, or other problems with the kidney.

IgA nephropathy is also called Berger disease.

Causes

IgA is a protein, called an antibody, that helps the body fight infections. IgA nephropathy occurs when too much of this protein is deposited in the kidneys. IgA builds up inside the small blood vessels of the kidney. Structures in the kidney called glomeruli become inflamed and damaged.

The disorder can appear suddenly (acute), or get worse slowly over many years (chronic glomerulonephritis).

Risk factors include:

  • A personal or family history of IgA nephropathy or Henoch Schonlein purpura, a form of vasculitis that affects many parts of the body
  • White or Asian ethnicity

IgA nephropathy can occur in people of all ages, but it most often affects males in their teens to late 30s.

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